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KMID : 0605720150210020113
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Journal of the Korean Society of Biological Therapies in Psychiatry
2015 Volume.21 No. 2 p.113 ~ p.121
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Factors Associated with Treatment Response to Acetylcholinesterase Inhibitors in Alzheimer’s Disease
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Han Song-Yi
Lee Mi-Ji
Kim Jeong-Lan
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Abstract
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Objectives：This study aimed to identify factors associated with patients’ improved scores on the Mini Mental State Examination(MMSE) improvement by comparing the total MMSE scores of patients with Alzheimer’s disease(AD) before and after acetylcholinesterase inhibitors(AChEIs) treatment.
Methods：Data from fifty-three outpatients with AD were analyzed in this retrospective study. The patients received AChEIs and were assessed using cognitive function tests two times at 12-month intervals. The cognitive function assessments included the Clinical Dementia Rating(CDR) and neuropsychological tests of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease(CERAD-K). Patients were assessed for depressive symptoms using a Revised Korean version of the Geriatric Depression Scale(GDS-KR). The patients with improved MMSE scores comprised the Responder group, whereas the patients with deteriorated or unimproved MMSE scores comprised the Non?Responder group. The demographic and neuropsychological factors between the two groups were analyzed using the Chi-square test, t-test and Mann-Whitney test. The paired t-test and Wilcoxon signed-rank test were used for comparing clinical responses within each group.
Results：Seventeen patients were included in the Responder group and thirty-six patients were included in the Non?Responder group. The baseline GDS-KR scores were significantly higher in the Responder group than in the Non-Responder group(p=0.018). The GDS-KR scores significantly decreased in the Responder group after 12 months(p=0.048). There was no difference between the two groups across cognitive subdomains.
Conclusion：This study suggests that cognitive improvement following AChEIs for AD is associated with the response of depressive symptoms.
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KEYWORD
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Alzheimer disease, Cholinesterase inhibitors, Depression, Cognition
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